Knee Replacement The future of knee replacement has arrived: outpatient surgery, planned in 3D for your anatomy.
Medically reviewed by Thomas D. Ferro, M.D.
NanoKnee® surgeons perform knee replacement as an outpatient procedure. Each surgery uses a patient-specific 3D surgical plan built from your CT scan, a muscle-sparing approach for appropriate candidates, and spinal anesthesia with sedation instead of general anesthesia. Most patients walk within 90 minutes and go home the same day.
Faster Recovery. Home the Same Day.
Across more than 12,600 knee replacements, NanoKnee patients routinely:
Return to sports and exercise, including many higher-impact activities, as cleared by their surgeon
Are on their feet within 30 minutes of surgery
Return home about two hours after their knee replacement
Every NanoKnee procedure starts with a 3D plan built from your own CT scan, so your implant is sized, positioned and aligned to your anatomy before surgery begins.
What Recovery Looks Like at NanoKnee, in Our Own Numbers
Figure
What It Measures
65minutes
Median time from surgery to first walk, across 876 NanoKnee patients. Half were walking sooner.
96%
Share of patients walking within two hours of surgery; 88% within 90 minutes.
125°
Median knee flexion measured in the recovery unit, across 720 patients (middle half: 120° to 134°).
Same day
Every NanoKnee knee replacement is performed as an outpatient procedure; you recover at home.
For comparison, in a prospective study across 19 hospitals, only 5.6% of total knee replacement patients walked on the day of surgery, and 70% had walked by the end of the following day.[15] NanoKnee figures are medians and proportions from NanoKnee post-anesthesia recovery records with data for each measure (walking: 876 patients; flexion: 720 patients). Individual results vary.
Comparison: NanoKnee vs. Traditional Knee Replacement
vs
Traditional Knee Replacement
Pre-Operative Plan
CT-based 3D plan built by biomedical engineers and approved by your surgeon
X-ray templating, often finalized in the operating room
Alignment
Personalized to your pre-arthritic anatomy (restricted inverse kinematic alignment)
Neutral mechanical alignment, the same target for every knee
Surgical Approach
Muscle-sparing approach, including subvastus, for appropriate candidates
Standard medial parapatellar approach through the quadriceps tendon
Anesthesia
Spinal anesthesia plus sedation
General anesthesia, still the most common choice nationally
Time to Walk
Median 65 minutes after surgery (876 patients)
In a 19-hospital study, 5.6% of patients walked on the day of surgery[15]
Where You Recover
At home, typically 1–2 hours after surgery
A hospital stay of one to three days is still common
Physical Therapy
Surgeon-guided home program with progress tracking in the NanoKnee app
Several weeks of outpatient physical therapy
The Surgeons of NanoKnee
Explore our nationwide network of board-certified, independent orthopedic surgeons who specialize in the NanoKnee procedure.
Vance Eberly, MD
Vance Eberly, MD
Dr. Vance Eberly's passion for orthopedic surgery is evident in his dedication to providing personalized care for patients with musculoskeletal issues. With a focus on utilizing the latest advancem...
A hip and knee replacement specialist and board-certified surgeon, Dr. Kristopher Collins, MD, is passionate about helping patients regain their mobility quickly and safely. He graduated from NYU L...
Dr. Thomas Ferro is a board-certified, fellowship-trained orthopedic surgeon with 30+ years of experience, founder of Nanoknee™, and medical director of the Nanoknee™ in Arroyo Grande, California. ...
Dr. Christopher K. Tkach is an Adult Reconstruction Specialist at NanoKnee®, specializing in advanced knee and hip replacement designed to restore mobility efficiently while preserving a natural fe...
Dr. Thomas Tkach, MD, is a board-certified orthopedic surgeon with over two decades of experience helping patients live with total freedom and confidence in their joints. He specializes in hip and ...
Dr. Aaron Eubanks, MD, FAAOS, brings elite skill to every NanoKnee procedure, leveraging his fellowship training to deliver high-quality orthopedic care that gets you back to moving freely. With ov...
As a knee and hip reconstruction specialist, Dr. Eli Ahdoot, DO, prioritizes precision through cutting-edge techniques, ensuring your new joint is strong, healthy, and anatomically aligned. He’s co...
Board-certified and fellowship-trained, Dr. Saluta has extensive experience in treating a multitude of bone and joint issues, including fracture fixation and complex reconstruction of the hip, knee...
Dr. Obi Osuji, MD, exemplifies the NanoKnee mission of helping patients reclaim their mobility and quality of life through performance-driven, precise procedures. He’s a fellowship-trained, board-c...
NanoKnee is proud to partner with Dr. Daniel Allison, MD, FACS. A graduate of Baylor College of Medicine, Dr. Allison is a board-certified, fellowship-trained orthopedic surgeon specializing in adv...
NanoKnee is proud to partner with Dr. Richard Buch, MD, director of the Dallas Limb Restoration Center. As a board-certified, fellowship-trained orthopedic surgeon, Dr. Buch has built a career in r...
Dr. Greg Habib is an experienced orthopedic surgeon who specializes in advanced care for hips and knees, including Nano Knee and Nano Hip replacements. He serves patients across the greater Pittsbu...
Meet Dr. Graeme Matthewson, a fellowship-trained sports medicine orthopedic surgeon at NanoKnee® helping patients move past shoulder, hip, knee, and ankle injuries and get back to the life they lov...
Getting back to the life you love shouldn't wait. Dr. Timothy J. Henderson brings advanced surgical training and a same-day approach to hip and knee replacement, so patients can move forward with c...
Questions about outpatient knee replacement, answered by the NanoKnee team. Here’s what patients ask most.
0102
I feel richly blessed that my knee surgery is such a positive and successful experience
I feel richly blessed that my knee surgery is such a positive and successful experience; thanks, to the skills of Dr. Thomas Ferro. Beginning with the initial office visit, when Dr. Ferro said I would run and play softball in 12 weeks after surgery, I felt totally confident and scheduled the surgery. Currently, I am 76 years young; pla...
I feel richly blessed that my knee surgery is such a positive and successful experience; thanks, to the skills of Dr. Thomas Ferro. Beginning with the initial office visit, when Dr. Ferro said I would run and play softball in 12 weeks after surgery, I felt totally confident and scheduled the surgery. Currently, I am 76 years young; playing softball on 3 teams; COED recreational, Age 50+ recreational, and Age 75+ Senior Softball Tournament Team. The KNEE function is great!
This was my first surgery; but no fear, and the entire process went smoothly. The indoctrination, surgery prep, surgery, recovery, home care instructions, nurse and therapist home visit arrangements, pain management, etc were "automatic." Although, my home is 90 miles from the clinic, there were no inconveniences.
I was tired of the pain before surgery and it never occurred to me that the knee may not function well. However, the NEW knee exceeds all I could have imagined. Dr. Ferro's experience, technique, and skill as reflected in the overall knee performance is the key issue for me. I am constantly reminded how lucky I am when I am complimented on how quickly and fast I move on the field; play much younger. The knee is stable, strong, seemingly unlimited motion, NO pain and, thereby, totally functional as normal. There are many senior players that I have encountered with knee replacements; but none better than this one. I feel proud to share with others (considering surgery), the successful experience I have with Dr. Ferro and provide more information than they may care to hear. I continue with therapy type exercises and weight training; 3-5 hrs/wk.
Question: Was I able to play in 12wks after surgery? YES. Almost to the day, I played in a Senior Softball Tournament at Huntington Beach, CA. Played every inning of 5 games over a two day span: and all knew I was back!!!!! The entire Staff at the Clinic shares my enthusiasm. Thanks to All and God Bless. AL
Allen Kumm
My experience with Dr. Carson at NanoKnee-Humble has been life changing.
My experience with Dr. Carson at NanoKnee-Humble has been life changing. I had my first knee surgeries as a teenager resulting in lifelong pain. After NanoKnee, I am 66 years old and my pain is almost non-existent. Dr. Carson is my hero, especially since I had other orthopedic surgeons refusing to do knee replacement. I highly recomme...
My experience with Dr. Carson at NanoKnee-Humble has been life changing. I had my first knee surgeries as a teenager resulting in lifelong pain. After NanoKnee, I am 66 years old and my pain is almost non-existent. Dr. Carson is my hero, especially since I had other orthopedic surgeons refusing to do knee replacement. I highly recommend Dr. Carson and NanoKnee.
What Makes NanoKnee Different from a Traditional Knee Replacement?
NanoKnee differs from a traditional knee replacement in four ways, and you can ask any surgeon about each one.
A 3D Surgical Plan
Your implant is sized, positioned and aligned on a 3D model built from your CT scan by biomedical engineers, and your surgeon approves the plan before surgery.
Personalized Alignment
Your plan restores the joint line and alignment your knee had before arthritis, rather than using the same neutral target for everyone. This allows your ligaments to function normally, for a balanced, natural-feeling knee.
A Muscle-Sparing Approach for Appropriate Candidates
Randomized trials show a quadriceps-sparing approach offers early advantages, such as less pain and faster recovery.[8] NanoKnee surgeons use these approaches for appropriate candidates, including the subvastus or “Southern” approach.
Outpatient Surgery Under Spinal Anesthesia
A meta-analysis of 20 studies and more than 580,000 cases found no increase in complication or readmission risk with outpatient knee replacement compared with inpatient surgery.[9] You go home the same day and recover with a home program.
How We Prevent the Most Common Knee Replacement Problems
When knee replacements fail early, the reasons are rarely the implant. In a review of revisions at six U.S. joint replacement centers, the leading causes were loosening, instability, infection, stiffness and malalignment, and the authors concluded that early failures are primarily surgeon-dependent.[1] Component position matters for the long term as well: in a series of 6,070 knee replacements, malpositioned components were associated with higher failure rates.[2]
And even when nothing fails, roughly one in five patients is not satisfied with the result.[3] That is why NanoKnee treats the plan as seriously as the operation. Every case is built in 3D from your CT scan, with the implant sized and aligned to your anatomy and ligament balance mapped through your range of motion, before your surgeon makes the first cut. A balanced, well-positioned knee is what gets patients back on their feet quickly and keeps them there.
Personalized Alignment for a Strong, Flexible Knee That Feels Like Yours
NanoKnee's 3D plan restores your joint surfaces and alignment to the shape your knee had before arthritis changed it, rather than fitting every patient to the same neutral target. The goal is a knee that feels like yours from day one.
What Should I Expect from the Procedure?
Your surgery is done as an outpatient procedure under spinal anesthesia with sedation, so you are comfortable and unaware during the operation without a general anesthetic. Surgery typically takes about 90 minutes. You will be helped to your feet within about 30 minutes of the procedure, and most patients go home within two hours. Your knee can bear weight and bend immediately.
What Should I Expect After Surgery?
Most NanoKnee patients recover with a home exercise program rather than formal outpatient therapy. Here is how a typical recovery unfolds:
The first two weeks: back to your routine. Between days 7 and 14, most patients are handling everyday tasks around the house and getting out on their own again.
Weeks two through four: building strength. Moderate activity returns as your home program progresses, with longer walks, stationary biking and more demanding exercises.
Weeks four through eight: an active life again. Most patients return to the active lifestyle they had planned for, at the pace your surgeon sets.
Published research finds that about 85% of knee replacement patients return to moderate-impact physical activities at a median of about four months.[4] Recovery varies from person to person, and your NanoKnee surgeon will set the pace that is right for you.
Staying active keeps your new knee strong. Activities that support your recovery and long-term joint health include:
Walking
Biking
Water aerobics
Tai chi
Yoga
Strengthening exercises
Tennis
Once you have healed, most patients return to the sports and activities they enjoy without restrictions.
Knee Replacement
Frequently Asked Questions
How long do knee replacements last?
Well-positioned knee replacements can last decades. The largest analysis of national joint registries found that about 82% of total knee replacements and 70% of partial knee replacements are still in place 25 years after surgery.[5]
How long does NanoKnee last?
NanoKnee focuses on the factors that support implant longevity. We combine precision 3D modeling and engineering with FDA-cleared implants to develop a unique plan that positions and aligns the implant to your anatomy. Component position and balance are among the factors within the surgical team's control that affect how long a knee replacement lasts.[2]
Am I a candidate for NanoKnee?
If you have been told you need a knee replacement and you want to recover at home, stay active, and have your implant planned for your own anatomy, you are likely a candidate. NanoKnee was developed for active patients who want the highest level of function after surgery, including younger patients and older adults in good general health. Candidacy depends on your imaging, health, history and goals, which your surgeon reviews at your consultation.
Is knee replacement safe?
Yes. Knee replacement is one of the most common and most studied operations in the United States; the American Joint Replacement Registry has recorded more than 4.4 million hip and knee replacements since 2012.[6] Serious complications are uncommon, and some risks depend on choices made before surgery.
In a national analysis of more than 380,000 joint replacements, spinal (neuraxial) anesthesia was associated with lower 30-day mortality and fewer in-hospital complications than general anesthesia.[7] NanoKnee procedures are performed under spinal anesthesia with sedation by board-certified orthopedic surgeons.
How is my implant aligned?
NanoKnee plans use restricted inverse kinematic alignment (iKA), a personalized approach that restores your natural tibial joint line and alignment within safe limits. Healthy knees are not all built the same; a substantial share of adults naturally stand with a knee that is not in “neutral” mechanical alignment.[10] In a matched series, patients whose knees were aligned this way reported higher satisfaction and better Oxford Knee Scores at one year than patients aligned to an adjusted mechanical target.[11] Your plan is built on your CT scan before surgery and reviewed by your surgeon.
Do I have alternatives to a total knee replacement?
Yes, if your arthritis is limited to part of the knee. NanoKnee surgeons perform partial (unicompartmental) and bicompartmental knee replacement, which resurface only the damaged one-third or two-thirds of the joint and preserve your ligaments and healthy bone. In a randomized trial of 528 patients with arthritis confined to the inner compartment, partial knee replacements achieved equivalent improvement with fewer complications.[12][13] The right choice depends on your anatomy and specific knee condition, which your NanoKnee surgeon will review with you.
What is the least invasive knee replacement?
For arthritis confined to one compartment, a Nano partial knee replacement is the least invasive option: it removes the least bone and preserves your ligaments.[12] For a total knee replacement, the planning and approach matter more than the incision length. NanoKnee’s advanced 3D modeling allows our surgeons to use a quadriceps-sparing approach for appropriate candidates, which reaches the joint without cutting the quadriceps tendon. Randomized trials show this approach reduces pain in the first days after surgery.[8]
What kind of anesthesia is used?
NanoKnee surgeons use spinal (regional) anesthesia with a local anesthetic block and “twilight” sedation, so you are comfortable and unaware during surgery without a general anesthetic. Spinal anesthesia has been associated with lower 30-day mortality and fewer complications than general anesthesia in a national analysis of more than 380,000 joint replacements.[7] General anesthesia is used only when it is the safer choice for a particular patient.
Will I stay in the hospital?
No. NanoKnee procedures are performed on an outpatient basis, and most patients leave the surgery center about two hours after their procedure. In a meta-analysis of 20 studies, appropriately selected outpatients had complication and readmission rates comparable to inpatients.[9] Your surgeon will confirm that same-day discharge is appropriate for you.
How long does knee replacement surgery take?
A NanoKnee procedure typically takes about 90 minutes. Because implant size, position and alignment are decided in your 3D plan before surgery, fewer decisions are made under time pressure in the operating room.
What is the recovery time after knee replacement?
Most NanoKnee patients are walking within 90 minutes of surgery and doing light activities in the first week. As a general guide:
7–14 days: routine daily activity
2–4 weeks: moderate activity
4–8 weeks: return to an active lifestyle
Recovery varies from patient to patient, and your surgeon will set your pace.
Will I need physical therapy?
Most NanoKnee patients recover with a surgeon-guided home exercise program rather than formal outpatient physical therapy. You begin walking, isometrics and stretching right away and progress to strengthening, biking and activities such as golf and hiking. The NanoKnee app lets you track your progress and communicate directly with your care team.
What activities can I return to? Can I run or ski?
Most NanoKnee patients return to the activities they enjoy, including hiking, cycling, golf, tennis, running and skiing.
Will I regain full range of motion?
Most NanoKnee patients regain the motion they need for daily life and sport, and many regain motion they had lost over years of arthritis. Your 3D plan is built to balance your ligaments through the full range of motion, which supports a knee that bends and straightens fully. In our recovery-unit records, the median immediate post-operative knee flexion across 720 NanoKnee patients was 125°, with half of patients between 120° and 134°.
How long does the incision take to heal, and will there be a scar?
Incisions are generally healed within two weeks, though you will protect the area for the first two to three months. NanoKnee procedures include a cosmetic, plastic-surgical closure to minimize scarring.
What are the risks and complications?
The risks of all knee replacements include infection, blood clots, stiffness, instability, implant loosening over time, and the risks of anesthesia. NanoKnee's surgical processes and proprietary 3D Blueprinting® address specific risks: spinal anesthesia is associated with fewer perioperative complications than general anesthesia,[7] and pre-operative 3D planning targets the position and balance problems that are among the leading causes of early revision.[1] Your NanoKnee surgeon will review the risks that apply to you.
Are there long-term side effects?
Most patients experience a progressive return of function and resolution of arthritis pain over the months after surgery. Some numbness near the incision and occasional clicking are common and usually not a concern. Your surgeon will follow your recovery and address anything that does not progress as expected.
Is NanoKnee covered by insurance, and what does it cost?
Knee replacement is covered by Medicare and most commercial health plans when medically necessary, and NanoKnee's surgery is billed as a knee replacement. The pre-operative 3D planning and engineering is not covered by insurance; depending on your plan, you may be responsible for up to $8,500 for it. Our patient navigators will confirm your coverage and any out-of-pocket cost before you commit to surgery, and financing is offered for non-covered portions.
Is knee replacement safe for seniors?
Yes. Knee replacement is performed routinely in older adults with advanced arthritis and can substantially improve mobility and quality of life. Candidacy depends on general health rather than age alone, and every NanoKnee patient is evaluated before surgery. Spinal anesthesia, which NanoKnee uses as standard, is associated with fewer perioperative complications than general anesthesia.[7]
Does NanoKnee use robotics or artificial intelligence?
No robot is used in the operating room, and your surgeon performs the procedure. AI is used only before surgery, to help our biomedical engineers build a 3D model from your CT scan; your surgeon reviews and approves the final plan. NanoKnee's precision comes from that pre-operative plan, not from technology in the operating room.
Sources
Schroer WC, Berend KR, Lombardi AV, Barnes CL, Bolognesi MP, Berend ME, Ritter MA, Nunley RM. Why are total knees failing today? Etiology of total knee revision in 2010 and 2011. J Arthroplasty. 2013;28(8 Suppl):116-119. doi:10.1016/j.arth.2013.04.056
Ritter MA, Davis KE, Meding JB, Pierson JL, Berend ME, Malinzak RA. The effect of alignment and BMI on failure of total knee replacement. J Bone Joint Surg Am. 2011;93(17):1588-1596. doi:10.2106/JBJS.J.00772
Bourne RB, Chesworth BM, Davis AM, Mahomed NN, Charron KDJ. Patient satisfaction after total knee arthroplasty: who is satisfied and who is not? Clin Orthop Relat Res. 2010;468(1):57-63.
Braz R, Gomes E, Valente C, Ahmed H, Moursy M, Delgado D, Sanchez M, Andrade R, Espregueira-Mendes J. High rate of return to low-impact physical activity or sports after total and unicompartmental knee arthroplasty: a systematic review with meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2026. doi:10.1002/ksa.70267
Evans JT, Walker RW, Evans JP, Blom AW, Sayers A, Whitehouse MR. How long does a knee replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up. Lancet. 2019;393(10172):655-663. doi:10.1016/S0140-6736(18)32531-5
American Academy of Orthopaedic Surgeons. American Joint Replacement Registry (AJRR): 2025 Annual Report. Rosemont, IL: AAOS; 2025.
Memtsoudis SG, Sun X, Chiu YL, Stundner O, Liu SS, Banerjee S, Mazumdar M, Sharrock NE. Perioperative comparative effectiveness of anesthetic technique in orthopedic patients. Anesthesiology. 2013;118(5):1046-1058. doi:10.1097/ALN.0b013e318286061d
Berstock JR, Murray JR, Whitehouse MR, Blom AW, Beswick AD. Medial subvastus versus the medial parapatellar approach for total knee replacement: a systematic review and meta-analysis of randomized controlled trials. EFORT Open Rev. 2018;3(3):78-84. doi:10.1302/2058-5241.3.170030
Gong S, Yi Y, Wang R, Han L, Gong T, Wang Y, Shao W, Feng Y, Xu W. Outpatient total knee and hip arthroplasty present comparable and even better clinical outcomes than inpatient operation. Front Surg. 2022;9:833275. doi:10.3389/fsurg.2022.833275
Bellemans J, Colyn W, Vandenneucker H, Victor J. The Chitranjan Ranawat Award: is neutral mechanical alignment normal for all patients? The concept of constitutional varus. Clin Orthop Relat Res. 2012;470(1):45-53.
Winnock de Grave P, Luyckx T, Claeys K, Tampere T, Kellens J, Müller J, Gunst P. Higher satisfaction after total knee arthroplasty using restricted inverse kinematic alignment compared to adjusted mechanical alignment. Knee Surg Sports Traumatol Arthrosc. 2022;30(2):488-499. doi:10.1007/s00167-020-06165-4
Beard DJ, Davies LJ, Cook JA, MacLennan G, Price A, Kent S, Hudson J, Carr A, Leal J, Campbell H, Fitzpatrick R, Arden N, Murray D, Campbell MK; TOPKAT Study Group. The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial. Lancet. 2019;394(10200):746-756. doi:10.1016/S0140-6736(19)31281-4
Beard DJ, Davies LJ, Cook JA, MacLennan G, Hudson J, Price AJ, Carr AJ, Little M, Leal J, Fitzpatrick R, Murray DW, Campbell MK; TOPKAT Study Group. Assessing clinical and cost effectiveness of total versus partial knee replacement (TOPKAT): 10-year follow-up of a multicentre, randomised controlled trial. Lancet Rheumatol. 2026;8(2):e116-e126. doi:10.1016/S2665-9913(25)00250-4
Witjes S, Gouttebarge V, Kuijer PPFM, van Geenen RCI, Poolman RW, Kerkhoffs GMMJ. Return to sports and physical activity after total and unicondylar knee arthroplasty: a systematic review and meta-analysis. Sports Med. 2016;46(2):269-292. doi:10.1007/s40279-015-0421-9
Chua MJ, Hart AJ, Mittal R, Harris IA, Xuan W, Naylor JM. Early mobilisation after total hip or knee arthroplasty: a multicentre prospective observational study. PLoS One. 2017;12(6):e0179820. doi:10.1371/journal.pone.0179820
Text Us
Hi there, have a question? Text us here.>
Enter your information, and our team will text you shortly.
Accessibility: If you are vision-impaired or have some other impairment covered by the Americans with Disabilities Act or a similar law, and you wish to discuss potential accommodations related to using this website, please contact our Accessibility Manager at (888) 492-0598.